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Intralesional interferon-alpha-2b for the treatment of Peyronie's disease.
Int J Impot Res. 2002 Oct; 14(5):336-9.IJ

Abstract

Peyronie's disease can best be described as a localized connective tissue disorder that primarily affects the tunica albuginea of the penis. The disease may be attributed to repetitive vascular trauma that initiates an inflammatory process and ultimately leads to the formation of a fibrous penile plaque. The plaque consists mainly of collagen and can significantly alter penile anatomy and function. Patients with Peyronie's disease will most often present with penile curvature, pain on erection, a palpable nodule most commonly located on the dorsal shaft of the penis, and erectile dysfunction. There is no definitive treatment for Peyronie's disease and the treating physician has many options. They may wait for spontaneous resolution of the plaque, choose medical therapy (which includes both oral and intralesional regimens), or opt for surgical management. The main purpose of this article is to discuss the advances in medical therapy for Peyronie's disease, in particular intralesional injection of interferon-alpha-2b (IFN-alpha-2b). Several studies have concluded that IFN-alpha-2b can be an effective modality of treatment and that many patients placed on a regimen of IFN-alpha-2b experienced a significant reduction in penile curvature, diminished pain with erection, and decreased size of the plaque. Further clinical studies are currently being undertaken to determine the precise quantity and frequency of administration of IFN-alpha-2b that is most effective with the least amount of side effects.

Authors+Show Affiliations

Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12454683

Citation

Lacy, G L., et al. "Intralesional Interferon-alpha-2b for the Treatment of Peyronie's Disease." International Journal of Impotence Research, vol. 14, no. 5, 2002, pp. 336-9.
Lacy GL, Adams DM, Hellstrom WJ. Intralesional interferon-alpha-2b for the treatment of Peyronie's disease. Int J Impot Res. 2002;14(5):336-9.
Lacy, G. L., Adams, D. M., & Hellstrom, W. J. (2002). Intralesional interferon-alpha-2b for the treatment of Peyronie's disease. International Journal of Impotence Research, 14(5), 336-9.
Lacy GL, Adams DM, Hellstrom WJ. Intralesional Interferon-alpha-2b for the Treatment of Peyronie's Disease. Int J Impot Res. 2002;14(5):336-9. PubMed PMID: 12454683.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intralesional interferon-alpha-2b for the treatment of Peyronie's disease. AU - Lacy,G L,2nd AU - Adams,D M, AU - Hellstrom,W J G, PY - 2002/11/28/pubmed PY - 2003/4/16/medline PY - 2002/11/28/entrez SP - 336 EP - 9 JF - International journal of impotence research JO - Int J Impot Res VL - 14 IS - 5 N2 - Peyronie's disease can best be described as a localized connective tissue disorder that primarily affects the tunica albuginea of the penis. The disease may be attributed to repetitive vascular trauma that initiates an inflammatory process and ultimately leads to the formation of a fibrous penile plaque. The plaque consists mainly of collagen and can significantly alter penile anatomy and function. Patients with Peyronie's disease will most often present with penile curvature, pain on erection, a palpable nodule most commonly located on the dorsal shaft of the penis, and erectile dysfunction. There is no definitive treatment for Peyronie's disease and the treating physician has many options. They may wait for spontaneous resolution of the plaque, choose medical therapy (which includes both oral and intralesional regimens), or opt for surgical management. The main purpose of this article is to discuss the advances in medical therapy for Peyronie's disease, in particular intralesional injection of interferon-alpha-2b (IFN-alpha-2b). Several studies have concluded that IFN-alpha-2b can be an effective modality of treatment and that many patients placed on a regimen of IFN-alpha-2b experienced a significant reduction in penile curvature, diminished pain with erection, and decreased size of the plaque. Further clinical studies are currently being undertaken to determine the precise quantity and frequency of administration of IFN-alpha-2b that is most effective with the least amount of side effects. SN - 0955-9930 UR - https://wwww.unboundmedicine.com/medline/citation/12454683/Intralesional_interferon_alpha_2b_for_the_treatment_of_Peyronie's_disease_ L2 - https://doi.org/10.1038/sj.ijir.3900867 DB - PRIME DP - Unbound Medicine ER -