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Muscle soreness and damage parameters after prolonged intermittent shuttle-running following acute vitamin C supplementation.
Int J Sports Med. 2001 Jan; 22(1):68-75.IJ

Abstract

Exercise-induced free-radical production may be partly responsible for muscle soreness and damage following demanding exercise. A number of studies have investigated the effect of antioxidant supplementation although there is a paucity of information regarding vitamin C. Therefore the aim of the present study was to investigate the effect of vitamin C supplementation on exercise-induced muscle soreness and damage. Nine habitually active males consumed a 1 g dose of vitamin C 2 h before exercise, and on another occasion consumed an identical placebo. The exercise comprised a 90 min intermittent shuttle-running test, which was designed to simulate the multiple-sprint sports. Vitamin C supplementation increased plasma concentrations of vitamin C before exercise, and plasma concentrations continued to increase during the shuttle-run to reach a peak of approximately 200 micromol x l(-1) immediately after exercise. However, muscle soreness, and markers of both muscle damage (creatine kinase and aspartate aminotransferase) and lipid peroxidation (malondialdehyde) were elevated to an equal extent after exercise in placebo and supplemented trials. Therefore acute supplementation with vitamin C had no beneficial effects although it is possible that such short-term vitamin C supplementation was ineffective because it occurred at an inappropriate time.

Authors+Show Affiliations

Human Muscle Metabolism Research Group, Loughborough University, Leicestershire, UK. d.thompson@bath.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11258644

Citation

Thompson, D, et al. "Muscle Soreness and Damage Parameters After Prolonged Intermittent Shuttle-running Following Acute Vitamin C Supplementation." International Journal of Sports Medicine, vol. 22, no. 1, 2001, pp. 68-75.
Thompson D, Williams C, Kingsley M, et al. Muscle soreness and damage parameters after prolonged intermittent shuttle-running following acute vitamin C supplementation. Int J Sports Med. 2001;22(1):68-75.
Thompson, D., Williams, C., Kingsley, M., Nicholas, C. W., Lakomy, H. K., McArdle, F., & Jackson, M. J. (2001). Muscle soreness and damage parameters after prolonged intermittent shuttle-running following acute vitamin C supplementation. International Journal of Sports Medicine, 22(1), 68-75.
Thompson D, et al. Muscle Soreness and Damage Parameters After Prolonged Intermittent Shuttle-running Following Acute Vitamin C Supplementation. Int J Sports Med. 2001;22(1):68-75. PubMed PMID: 11258644.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Muscle soreness and damage parameters after prolonged intermittent shuttle-running following acute vitamin C supplementation. AU - Thompson,D, AU - Williams,C, AU - Kingsley,M, AU - Nicholas,C W, AU - Lakomy,H K, AU - McArdle,F, AU - Jackson,M J, PY - 2001/3/22/pubmed PY - 2001/5/18/medline PY - 2001/3/22/entrez SP - 68 EP - 75 JF - International journal of sports medicine JO - Int J Sports Med VL - 22 IS - 1 N2 - Exercise-induced free-radical production may be partly responsible for muscle soreness and damage following demanding exercise. A number of studies have investigated the effect of antioxidant supplementation although there is a paucity of information regarding vitamin C. Therefore the aim of the present study was to investigate the effect of vitamin C supplementation on exercise-induced muscle soreness and damage. Nine habitually active males consumed a 1 g dose of vitamin C 2 h before exercise, and on another occasion consumed an identical placebo. The exercise comprised a 90 min intermittent shuttle-running test, which was designed to simulate the multiple-sprint sports. Vitamin C supplementation increased plasma concentrations of vitamin C before exercise, and plasma concentrations continued to increase during the shuttle-run to reach a peak of approximately 200 micromol x l(-1) immediately after exercise. However, muscle soreness, and markers of both muscle damage (creatine kinase and aspartate aminotransferase) and lipid peroxidation (malondialdehyde) were elevated to an equal extent after exercise in placebo and supplemented trials. Therefore acute supplementation with vitamin C had no beneficial effects although it is possible that such short-term vitamin C supplementation was ineffective because it occurred at an inappropriate time. SN - 0172-4622 UR - https://wwww.unboundmedicine.com/medline/citation/11258644/Muscle_soreness_and_damage_parameters_after_prolonged_intermittent_shuttle_running_following_acute_vitamin_C_supplementation_ L2 - https://www.thieme-connect.com/DOI/DOI?10.1055/s-2001-11358 DB - PRIME DP - Unbound Medicine ER -