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Gamma-hydroxybutyrate overdose and physostigmine: teaching new tricks to an old drug?
Ann Emerg Med. 2001 Jan; 37(1):99-102.AE

Abstract

Gamma-hydroxybutyrate was introduced as an anesthetic agent in the 1960s and is still used in some countries, despite recognized disadvantages. More recently, it has emerged as a popular recreational drug. We report 3 cases of gamma-hydroxybutyrate overdose, the effects of which were reversed by the administration of low-dose intravenous physostigmine. The origins of this regimen and the case for physostigmine as a potential antidote are described.

Authors+Show Affiliations

Emergency Department, Royal Adelaide Hospital, Adelaide, SA, Australia.No affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

11145779

Citation

Caldicott, D G., and M Kuhn. "Gamma-hydroxybutyrate Overdose and Physostigmine: Teaching New Tricks to an Old Drug?" Annals of Emergency Medicine, vol. 37, no. 1, 2001, pp. 99-102.
Caldicott DG, Kuhn M. Gamma-hydroxybutyrate overdose and physostigmine: teaching new tricks to an old drug? Ann Emerg Med. 2001;37(1):99-102.
Caldicott, D. G., & Kuhn, M. (2001). Gamma-hydroxybutyrate overdose and physostigmine: teaching new tricks to an old drug? Annals of Emergency Medicine, 37(1), 99-102.
Caldicott DG, Kuhn M. Gamma-hydroxybutyrate Overdose and Physostigmine: Teaching New Tricks to an Old Drug. Ann Emerg Med. 2001;37(1):99-102. PubMed PMID: 11145779.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gamma-hydroxybutyrate overdose and physostigmine: teaching new tricks to an old drug? AU - Caldicott,D G, AU - Kuhn,M, PY - 2001/1/6/pubmed PY - 2001/3/3/medline PY - 2001/1/6/entrez SP - 99 EP - 102 JF - Annals of emergency medicine JO - Ann Emerg Med VL - 37 IS - 1 N2 - Gamma-hydroxybutyrate was introduced as an anesthetic agent in the 1960s and is still used in some countries, despite recognized disadvantages. More recently, it has emerged as a popular recreational drug. We report 3 cases of gamma-hydroxybutyrate overdose, the effects of which were reversed by the administration of low-dose intravenous physostigmine. The origins of this regimen and the case for physostigmine as a potential antidote are described. SN - 0196-0644 UR - https://wwww.unboundmedicine.com/medline/citation/11145779/Gamma_hydroxybutyrate_overdose_and_physostigmine:_teaching_new_tricks_to_an_old_drug L2 - https://linkinghub.elsevier.com/retrieve/pii/S0196-0644(01)96501-1 DB - PRIME DP - Unbound Medicine ER -