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Vitamin E supplementation attenuates leakage of enzymes following 6 successive days of running training.
Int J Sports Med. 2000 Jul; 21(5):369-74.IJ

Abstract

The purpose of this study was to examine whether vitamin E supplementation in humans would attenuate an increase of serum enzymes as an indirect marker of muscle damage following a sudden large increase in the running distance in a 6-day running training or not. A randomized and placebo-controlled study was carried out on fourteen male runners who were supplied vitamin E (alpha-tocopherol 1200 IU x day(-1); E) or placebo (P) 4 weeks prior to (T1) and during 6 successive days of running training (48.3 +/- 5.7 km x day(-1), means +/- SD). Resting venous blood samples were obtained before maximal treadmill running, at T1, the day immediately before (T2), the next day (T3), and three weeks (T4) after the running training. Serum levels of alpha-tocopherol, lipid peroxidation products (thiobarbituric acid; TBA), creatine kinase (CK), lactate dehydrogenase (LDH), and LDH isozyme 1-5 were quantitatively analyzed. No significant difference was found in maximal oxygen uptake (VO2max) and maximal heart rates following the exhaustive exercise between the P and E group during the experiments. Vitamin E supplementation significantly increased serum alpha-tocopherol (p<0.001) and decreased TBA levels (p < 0.001) compared with pre-supplementation levels. Although serum CK and LDH activities increased significantly at T3 in either group, significantly lower CK (p < 0.05) and LDH (p < 0.001) levels were observed in the E group compared with the P group. The ratio of LDH1 to LDH2 (LDH1/LDH2) decreased significantly at T3 in either group compared with the T1 levels, since there was no significant difference in the LDH1/LDH2 between the P and E group throughout the experiments. These results indicate that vitamin E supplementation can reduce the leakage of CK and LDH following 6 successive days of endurance running. The protective effect of vitamin E against free radicals probably inhibits free-radical-induced muscle damage caused by a sudden large increase in the running distance.

Authors+Show Affiliations

Department of General Studies, Nagoya Institute of Technology, Japan. itoh@ks.kyy.nitech.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10950448

Citation

Itoh, H, et al. "Vitamin E Supplementation Attenuates Leakage of Enzymes Following 6 Successive Days of Running Training." International Journal of Sports Medicine, vol. 21, no. 5, 2000, pp. 369-74.
Itoh H, Ohkuwa T, Yamazaki Y, et al. Vitamin E supplementation attenuates leakage of enzymes following 6 successive days of running training. Int J Sports Med. 2000;21(5):369-74.
Itoh, H., Ohkuwa, T., Yamazaki, Y., Shimoda, T., Wakayama, A., Tamura, S., Yamamoto, T., Sato, Y., & Miyamura, M. (2000). Vitamin E supplementation attenuates leakage of enzymes following 6 successive days of running training. International Journal of Sports Medicine, 21(5), 369-74.
Itoh H, et al. Vitamin E Supplementation Attenuates Leakage of Enzymes Following 6 Successive Days of Running Training. Int J Sports Med. 2000;21(5):369-74. PubMed PMID: 10950448.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin E supplementation attenuates leakage of enzymes following 6 successive days of running training. AU - Itoh,H, AU - Ohkuwa,T, AU - Yamazaki,Y, AU - Shimoda,T, AU - Wakayama,A, AU - Tamura,S, AU - Yamamoto,T, AU - Sato,Y, AU - Miyamura,M, PY - 2000/8/19/pubmed PY - 2001/2/28/medline PY - 2000/8/19/entrez SP - 369 EP - 74 JF - International journal of sports medicine JO - Int J Sports Med VL - 21 IS - 5 N2 - The purpose of this study was to examine whether vitamin E supplementation in humans would attenuate an increase of serum enzymes as an indirect marker of muscle damage following a sudden large increase in the running distance in a 6-day running training or not. A randomized and placebo-controlled study was carried out on fourteen male runners who were supplied vitamin E (alpha-tocopherol 1200 IU x day(-1); E) or placebo (P) 4 weeks prior to (T1) and during 6 successive days of running training (48.3 +/- 5.7 km x day(-1), means +/- SD). Resting venous blood samples were obtained before maximal treadmill running, at T1, the day immediately before (T2), the next day (T3), and three weeks (T4) after the running training. Serum levels of alpha-tocopherol, lipid peroxidation products (thiobarbituric acid; TBA), creatine kinase (CK), lactate dehydrogenase (LDH), and LDH isozyme 1-5 were quantitatively analyzed. No significant difference was found in maximal oxygen uptake (VO2max) and maximal heart rates following the exhaustive exercise between the P and E group during the experiments. Vitamin E supplementation significantly increased serum alpha-tocopherol (p<0.001) and decreased TBA levels (p < 0.001) compared with pre-supplementation levels. Although serum CK and LDH activities increased significantly at T3 in either group, significantly lower CK (p < 0.05) and LDH (p < 0.001) levels were observed in the E group compared with the P group. The ratio of LDH1 to LDH2 (LDH1/LDH2) decreased significantly at T3 in either group compared with the T1 levels, since there was no significant difference in the LDH1/LDH2 between the P and E group throughout the experiments. These results indicate that vitamin E supplementation can reduce the leakage of CK and LDH following 6 successive days of endurance running. The protective effect of vitamin E against free radicals probably inhibits free-radical-induced muscle damage caused by a sudden large increase in the running distance. SN - 0172-4622 UR - https://wwww.unboundmedicine.com/medline/citation/10950448/Vitamin_E_supplementation_attenuates_leakage_of_enzymes_following_6_successive_days_of_running_training_ L2 - https://www.thieme-connect.com/DOI/DOI?10.1055/s-2000-3777 DB - PRIME DP - Unbound Medicine ER -