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Physostigmine in the treatment of gamma-hydroxybutyric acid overdose.
Mayo Clin Proc. 2000 Apr; 75(4):401-2.MC

Abstract

The widespread abuse of the recreational drug gamma-hydroxybutyric acid has resulted in several reports of overdose leading to coma. The use of a short-acting anticholinesterase agent such as physostigmine as a potential reversal agent has been proposed previously. We report 2 cases of gamma-hydroxybutyric acid-induced coma that rapidly reversed with intravenous administration of physostigmine.

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Authors+Show Affiliations

Yates SW
North Texas Medical Group, Colony 75056-2062, USA.
Viera AJ
No affiliation info available

MeSH

AdultCholinesterase InhibitorsDrug OverdoseFemaleHumansHydroxybutyratesMalePhysostigmineTreatment Outcome

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

10761496

Citation

Yates, S W., and A J. Viera. "Physostigmine in the Treatment of Gamma-hydroxybutyric Acid Overdose." Mayo Clinic Proceedings, vol. 75, no. 4, 2000, pp. 401-2.
Yates SW, Viera AJ. Physostigmine in the treatment of gamma-hydroxybutyric acid overdose. Mayo Clin Proc. 2000;75(4):401-2.
Yates, S. W., & Viera, A. J. (2000). Physostigmine in the treatment of gamma-hydroxybutyric acid overdose. Mayo Clinic Proceedings, 75(4), 401-2.
Yates SW, Viera AJ. Physostigmine in the Treatment of Gamma-hydroxybutyric Acid Overdose. Mayo Clin Proc. 2000;75(4):401-2. PubMed PMID: 10761496.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Physostigmine in the treatment of gamma-hydroxybutyric acid overdose. AU - Yates,S W, AU - Viera,A J, PY - 2000/4/13/pubmed PY - 2000/5/8/medline PY - 2000/4/13/entrez SP - 401 EP - 2 JF - Mayo Clinic proceedings JO - Mayo Clin Proc VL - 75 IS - 4 N2 - The widespread abuse of the recreational drug gamma-hydroxybutyric acid has resulted in several reports of overdose leading to coma. The use of a short-acting anticholinesterase agent such as physostigmine as a potential reversal agent has been proposed previously. We report 2 cases of gamma-hydroxybutyric acid-induced coma that rapidly reversed with intravenous administration of physostigmine. SN - 0025-6196 UR - https://wwww.unboundmedicine.com/medline/citation/10761496/Physostigmine_in_the_treatment_of_gamma_hydroxybutyric_acid_overdose_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0025-6196(11)64037-8 DB - PRIME DP - Unbound Medicine ER -