Physostigmine in the treatment of gamma-hydroxybutyric acid overdose.Mayo Clin Proc. 2000 Apr; 75(4):401-2.MC
The widespread abuse of the recreational drug gamma-hydroxybutyric acid has resulted in several reports of overdose leading to coma. The use of a short-acting anticholinesterase agent such as physostigmine as a potential reversal agent has been proposed previously. We report 2 cases of gamma-hydroxybutyric acid-induced coma that rapidly reversed with intravenous administration of physostigmine.