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A pilot study demonstrating clinical benefit from intralesional interferon alpha 2B in the treatment of Peyronie's disease.
J Androl. 1999 Jul-Aug; 20(4):444-8.JA

Abstract

Intralesional therapy is a less invasive method for the treatment of Peyronie's disease. The objective of this study was to evaluate intralesional injections of interferon alpha 2B (IFN-alpha-2B) as an effective alternative to the surgical treatment of Peyronie's disease. Twenty-one patients with Peyronie's disease were evaluated by use of penile duplex Doppler ultrasonography for cavernosal blood flows, degree of penile curvature, and plaque size. A questionnaire was given to all patients to assess sexual function. Each patient then received biweekly intralesional injections of 1 x 10(6) units of IFN-alpha-2B in 10 ml of normal saline over a period of 6 months. There was no placebo control group in this study. At the conclusion of the study, penile duplex Doppler imaging was repeated. A questionnaire was completed by all patients to assess changes in sexual function after treatment. Twenty patients completed the study, with all men reporting subjective softening of their plaques. Nine of 10 patients initially reporting penile pain with erection (90%) had resolution of their phallalgia while on study protocol. Thirteen patients (65%) had significant improvement in curvature, ranging from 20 to 90%. Seventeen patients (85%) demonstrated an objective 10 to 80% decrease in plaque size. Biweekly intralesional injections of Peyronie's plaques with IFN-alpha-2B resulted in a significant improvement in penile curvature, diminished pain, and reduced plaque size, and resulted in a subjective improvement in sexual function.

Authors+Show Affiliations

Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana 70112-2699, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

10452584

Citation

Ahuja, S, et al. "A Pilot Study Demonstrating Clinical Benefit From Intralesional Interferon Alpha 2B in the Treatment of Peyronie's Disease." Journal of Andrology, vol. 20, no. 4, 1999, pp. 444-8.
Ahuja S, Bivalacqua TJ, Case J, et al. A pilot study demonstrating clinical benefit from intralesional interferon alpha 2B in the treatment of Peyronie's disease. J Androl. 1999;20(4):444-8.
Ahuja, S., Bivalacqua, T. J., Case, J., Vincent, M., Sikka, S. C., & Hellstrom, W. J. (1999). A pilot study demonstrating clinical benefit from intralesional interferon alpha 2B in the treatment of Peyronie's disease. Journal of Andrology, 20(4), 444-8.
Ahuja S, et al. A Pilot Study Demonstrating Clinical Benefit From Intralesional Interferon Alpha 2B in the Treatment of Peyronie's Disease. J Androl. 1999 Jul-Aug;20(4):444-8. PubMed PMID: 10452584.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A pilot study demonstrating clinical benefit from intralesional interferon alpha 2B in the treatment of Peyronie's disease. AU - Ahuja,S, AU - Bivalacqua,T J, AU - Case,J, AU - Vincent,M, AU - Sikka,S C, AU - Hellstrom,W J, PY - 1999/8/19/pubmed PY - 1999/8/19/medline PY - 1999/8/19/entrez SP - 444 EP - 8 JF - Journal of andrology JO - J Androl VL - 20 IS - 4 N2 - Intralesional therapy is a less invasive method for the treatment of Peyronie's disease. The objective of this study was to evaluate intralesional injections of interferon alpha 2B (IFN-alpha-2B) as an effective alternative to the surgical treatment of Peyronie's disease. Twenty-one patients with Peyronie's disease were evaluated by use of penile duplex Doppler ultrasonography for cavernosal blood flows, degree of penile curvature, and plaque size. A questionnaire was given to all patients to assess sexual function. Each patient then received biweekly intralesional injections of 1 x 10(6) units of IFN-alpha-2B in 10 ml of normal saline over a period of 6 months. There was no placebo control group in this study. At the conclusion of the study, penile duplex Doppler imaging was repeated. A questionnaire was completed by all patients to assess changes in sexual function after treatment. Twenty patients completed the study, with all men reporting subjective softening of their plaques. Nine of 10 patients initially reporting penile pain with erection (90%) had resolution of their phallalgia while on study protocol. Thirteen patients (65%) had significant improvement in curvature, ranging from 20 to 90%. Seventeen patients (85%) demonstrated an objective 10 to 80% decrease in plaque size. Biweekly intralesional injections of Peyronie's plaques with IFN-alpha-2B resulted in a significant improvement in penile curvature, diminished pain, and reduced plaque size, and resulted in a subjective improvement in sexual function. SN - 0196-3635 UR - https://wwww.unboundmedicine.com/medline/citation/10452584/A_pilot_study_demonstrating_clinical_benefit_from_intralesional_interferon_alpha_2B_in_the_treatment_of_Peyronie's_disease_ DB - PRIME DP - Unbound Medicine ER -