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26,929 results
  • Safety and efficacy of anti-PD-1 in patients with baseline cardiac, renal, or hepatic dysfunction. [Journal Article]
  • JIJ Immunother Cancer 2016; 4:60
  • Kanz BA, Pollack MH, … Johnson DB
  • CONCLUSIONS: In our experience, anti-PD-1 agents in this group of patients with cardiac, hepatic or renal dysfunction were associated with tolerable irAEs and infrequent manageable worsening of organ dysfunction. Further, objective responses and prolonged PFS were observed in a number of patients. Thus, patients with baseline organ dysfunction may be considered for anti-PD-1 therapy with appropriate clinical monitoring.
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